Opening the Patient in Open Access Week; or, the Great Research Hoax

At first glance, The Atlantic’s “Lies, Damned Lies, and Medical Science,” by David H. Freedman (November, 2010), about the inaccuracies, contradictions, reversals, and errors in medical and pharmaceutical research, looks like something out of the National Enquirer: can this hoax be, to this extent, true? Alas, Dr. John Ioannidis’s 2005 article, published in JAMA, goes…